Effect of weight loss by a low-fat diet and a low-carbohydrate diet on peptide YY levels
| Autor: | Sakita N. Sistrun, J R Levy, John E. Nestler, Susan M. Kelly, Paulina A. Essah |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
Male medicine.medical_specialty Diet Reducing Endocrinology Diabetes and Metabolism Medicine (miscellaneous) 030209 endocrinology & metabolism 030204 cardiovascular system & hematology low-fat diet Energy homeostasis Article Body Mass Index 03 medical and health sciences Diet Carbohydrate-Restricted low-carbohydrate diet 0302 clinical medicine Weight loss Internal medicine Weight Loss medicine Humans Peptide YY Obesity Prospective Studies Diet Fat-Restricted 2. Zero hunger Nutrition and Dietetics PYY business.industry Area under the curve Carbohydrate medicine.disease Postprandial Period Endocrinology Postprandial Female medicine.symptom business Body mass index |
| Zdroj: | International journal of obesity (2005) |
| ISSN: | 1476-5497 |
| Popis: | To compare the effects of weight loss by an energy-restricted low-fat diet vs low-carbohydrate diet on serum peptide YY (PYY) levels.8-Week prospective study of 30 obese adults (mean age: 42.8+/-2.0 years, mean body mass index 35.5+/-0.6 kg m(-2)).After 8 weeks, subjects on the low-carbohydrate diet lost substantially more weight than those on the low-fat diet (5.8 vs 0.99 kg, P0.001). Weight loss by either diet resulted in a 9% reduction in both mean fasting serum PYY levels (baseline: 103.5+/-8.8 pg ml(-1), after weight loss: 94.1+/-6.5 pg ml(-1), P0.01) and postprandial area under the curve (AUC) PYY (baseline: (20.5+/-1.5) x 10(3) pg h(-1) ml(-1), after weight loss: mean AUC PYY (18.8+/-1.4) x 10(3) pg h(-1) ml(-1), P0.001). There was a trend towards lower levels of PYY with greater degrees of weight loss.Reduced PYY levels after weight loss by an energy-restricted low-fat or low-carbohydrate diet likely represents a compensatory response to maintain energy homeostasis and contributes to difficulty in weight loss during energy-restricted diets. |
| Databáze: | OpenAIRE |
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