Prevalence of antiphospholipid antibodies in patients with overt myocardial dysfunction in systemic lupus erythematosus. A case-control study
| Autor: | Varun Dhir, Shefali Khanna Sharma, Jasmina Ahluwalia, Ashwani Sood, Atit A Gawalkar, Aman Sharma, Ajay Bahl |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male Young Adult Rheumatology Prevalence Humans Lupus Erythematosus Systemic Medicine In patient biology business.industry Case-control study Middle Aged Cross-Sectional Studies Immunoglobulin M Echocardiography beta 2-Glycoprotein I Antibodies Anticardiolipin Case-Control Studies Immunoglobulin G Lupus Coagulation Inhibitor Immunology Antibodies Antiphospholipid biology.protein Female Antibody Cardiomyopathies business |
| Zdroj: | Lupus. 29:1503-1508 |
| ISSN: | 1477-0962 0961-2033 |
| Popis: | Background Small case-series have reported overt myocardial dysfunction to be associated with positive antiphospholipid antibodies in patients of systemic lupus erythematosus (SLE). However, there is no case-control study that has examined this association. Methods This case-control study recruited patients of SLE (fulfilling SLICC criteria) with overt myocardial dysfunction as cases and those without this as controls. Overt myocardial dysfunction was defined by echocardiography as global left ventricular dysfunction and reduced ejection fraction (Results This study included 51 patients (21 cases and 30 controls) having a mean (SD) age of 33 (13.3) years, and disease duration (median, IQR) of 28 months (12−38 months). The mean ejection fraction of cases was 31.7 (9.3)% while that of controls was 55.7 (1.7)% (p = 0.03). The frequency (percentage) of positive antiphospholipid antibodies was not significantly different between cases and controls (43%, 40%, p = 0.8). The frequency (percentage) of anti-cardiolipin antibody was also not significant between the groups (38%, 37%, p = 0.57). Serositis and leucopenia were more prevalent in SLE patients with myocardial dysfunction (p = 0.005). Conclusion This study did not find any significant association of anti-phospholipid antibodies with overt myocardial dysfunction in patients of SLE. |
| Databáze: | OpenAIRE |
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