Catechol activation in rat rostral ventrolateral medulla after systemic isocapnic metabolic acidosis
| Autor: | Nicolas Rentero, N. Bruandet, B. Milne, Luc Quintin |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Male
medicine.medical_specialty Mean arterial pressure Sympathetic nervous system Time Factors Physiology Partial Pressure Catechols Adrenergic Blood Pressure Adrenergic Neurons Rats Sprague-Dawley Heart Rate Physiology (medical) Internal medicine medicine Animals Medulla Acidosis Neurons Brain Mapping Medulla Oblongata Chemistry Respiration Metabolic acidosis Rostral ventrolateral medulla Carbon Dioxide Hydrogen-Ion Concentration medicine.disease Denervation Rats Endocrinology medicine.anatomical_structure Carotid Sinus Hydrochloric Acid medicine.symptom |
| Zdroj: | The American journal of physiology. 275(2) |
| ISSN: | 0002-9513 |
| Popis: | The catechol signal recorded using in vivo voltammetry within the rat rostral ventrolateral medulla (RVLM) can be interpreted as a catechol-specific index of the integrated activity of RVLM adrenergic barosensitive bulbospinal and nonbulbospinal neurons. To test the hypothesis that systemic acidosis leads to the activation of RVLM adrenergic neurons, the RVLM catechol signal was observed in rats after mild systemic acidosis (pH 7.20–7.25 for 30 min) induced by 1 M HCl under halothane anesthesia, controlled mechanical ventilation, and continuous infusion of Ringer lactate. Particular attention was paid to ensure that changes in mean arterial pressure (MAP) were + next to the surface of the ventrolateral medulla. |
| Databáze: | OpenAIRE |
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