A Review of the Association Between Parkinson Disease and Malignant Melanoma
| Autor: | Peter K. Lee, Sarah S. Schram, Max Disse, Hilary C. Reich |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Oncology medicine.medical_specialty Levodopa Skin Neoplasms Neurology Skin Pigmentation Dermatology Disease Environment Antiparkinson Agents 03 medical and health sciences 0302 clinical medicine Breast cancer Risk Factors Internal medicine Humans Medicine Genetic Predisposition to Disease Family history Melanoma business.industry Cancer Parkinson Disease General Medicine medicine.disease 030104 developmental biology Immunology Etiology Surgery business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Dermatologic Surgery. 42:141-146 |
| ISSN: | 1076-0512 |
| Popis: | Background An association between melanoma and Parkinson disease (PD) has been hinted at in the neurology and oncology literature since the 1970s after the initiation of levodopa (L-DOPA) therapy for PD. Given that L-DOPA is a substrate in melanin synthesis, there existed a concern that this therapy might cause melanoma. Objective The objective was to research possible etiological links to explain the connection between PD and melanoma. Methods A PubMed and Google Scholar literature search was performed using access provided by the University of Minnesota biomedical library. Results Patients with PD have an overall decreased risk of cancer diagnoses. However, breast cancer and melanoma have an uncharacteristically high rate of co-occurrence with PD. Family history of melanoma and lighter hair and skin color confer a higher risk of developing PD, and having a first-degree relative with either disease conveys a significantly increased risk of developing the other. Other possible connections that have been explored include pigmentation genes in neural-derived cells, pesticides, MC1R polymorphisms, and abnormal cellular autophagy. Conclusion Although a link between PD and melanoma exists, the etiology of this link continues to be elusive. Both PD and melanoma are likely multifactorial diseases involving genetic and environmental risk factors. |
| Databáze: | OpenAIRE |
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