Acetylcholine-induced inhibition of responses to field stimulation in rabbit pulmonary artery is unaffected by endothelium removal
| Autor: | R E Loiacono, David F. Story |
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| Rok vydání: | 1984 |
| Předmět: |
Male
medicine.medical_specialty Contraction (grammar) Endothelium Muscle Relaxation Pharmaceutical Science In Vitro Techniques Pulmonary Artery Clonidine Muscle Smooth Vascular Internal medicine medicine.artery Isometric Contraction medicine Animals Pharmacology Lagomorpha biology Chemistry Anatomy biology.organism_classification Acetylcholine Electric Stimulation Endocrinology medicine.anatomical_structure Pulmonary artery Female Rabbits medicine.drug Blood vessel Artery |
| Zdroj: | The Journal of pharmacy and pharmacology. 36(4) |
| ISSN: | 0022-3573 |
| Popis: | Acetylcholine (0·01–10 μmol litre−1) relaxed normal rings (endothelium-retained) of rabbit pulmonary artery precontracted with clonidine (10 μmol litre−1) while preparations with the endothelium removed responded with contraction only. Removal of the endothelium had no effect on contractions of the preparation to clonidine or field stimulation of the adventitial nerves (2 Hz, 10 s). Furthermore, the inhibitory effect of acetylcholine (0·3 and 1·0 μmol litre−1) on contractions induced by field stimulation was not influenced by the vascular endothelium. |
| Databáze: | OpenAIRE |
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