Gating of social reward by oxytocin in the ventral tegmental area
| Autor: | Jessica J. Walsh, Gül Dölen, Sophie Neuner, Kevin T. Beier, Liqun Luo, Matthew Wright, Eastman M. Lewis, Lin W. Hung, Jai S. Polepalli, Robert C. Malenka, Karl Deisseroth |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Presynaptic Terminals Gating Biology Oxytocin 03 medical and health sciences Mice 0302 clinical medicine Reward Dopamine medicine Animals Interpersonal Relations Axon Social Behavior Mice Knockout Multidisciplinary Integrases Dopaminergic Neurons Ventral Tegmental Area Ventral tegmental area 030104 developmental biology medicine.anatomical_structure Prosocial behavior Excitatory postsynaptic potential Neuroscience Nucleus 030217 neurology & neurosurgery medicine.drug Paraventricular Hypothalamic Nucleus |
| Zdroj: | Science (New York, N.Y.). 357(6358) |
| ISSN: | 1095-9203 |
| Popis: | Brain circuits that modulate sociability Understanding the neural mechanisms that mediate social reward has important societal and clinical implications. Hung et al. found that release of the neuropeptide oxytocin in the ventral tegmental area of the brain increased prosocial behaviors in mice (see the Perspective by Preston). Optogenetic manipulation of oxytocin release influenced sociability in a context-dependent manner. Oxytocin increased activity in dopamine cells that project to the nucleus accumbens, another key node of reward circuitry in the brain. Science , this issue p. 1406 ; see also p. 1353 |
| Databáze: | OpenAIRE |
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