Effects of diet composition on weight loss, metabolic factors and biomarkers in a 1-year weight loss intervention in obese women examined by baseline insulin resistance status
| Autor: | Loki Natarajan, Elizabeth L. Quintana, Cheryl L. Rock, Brinda K. Rana, Shirley W. Flatt, Bilge Pakiz, Dennis D. Heath |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Diet composition Weight loss Endocrinology Diabetes and Metabolism Overweight Breast cancer Endocrinology Sex hormone-binding globulin Sex Hormone-Binding Globulin Cancer biology Diabetes Reducing Stroke C-Reactive Protein Inflammation Mediators medicine.symptom medicine.medical_specialty Diet Reducing Clinical Sciences Juglans Article Endocrinology & Metabolism 03 medical and health sciences Insulin resistance Clinical Research Internal medicine Weight Loss Dietary Carbohydrates medicine Obesity Risk factor Metabolic and endocrine Nutrition 030109 nutrition & dietetics Walnuts Interleukin-6 Prevention medicine.disease Estrogen Dietary Fats Hormones Diet biology.protein Insulin Resistance Body mass index Biomarkers Follow-Up Studies |
| Zdroj: | Metabolism: clinical and experimental, vol 65, iss 11 |
| ISSN: | 0026-0495 |
| DOI: | 10.1016/j.metabol.2016.07.008 |
| Popis: | BackgroundObesity is a risk factor for postmenopausal breast cancer incidence and premenopausal and postmenopausal breast cancer mortality, which may be explained by several metabolic and hormonal factors (sex hormones, insulin resistance, and inflammation) that are biologically related. Differential effects of dietary composition on weight loss and these metabolic factors may occur in insulin-sensitive vs. insulin-resistant obese women.ObjectiveTo examine the effect of diet composition on weight loss and metabolic, hormonal and inflammatory factors in overweight/obese women stratified by insulin resistance status in a 1-year weight loss intervention.Methods and resultsNondiabetic women who were overweight/obese (n=245) were randomly assigned to a lower fat (20% energy), higher carbohydrate (65% energy) diet; a lower carbohydrate (45% energy), higher fat (35% energy) diet; or a walnut-rich (18% energy), higher fat (35% energy), lower carbohydrate (45% energy) diet. All groups lost weight at follow-up (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect