Therapeutic targets and microenvironment in sequential biopsies of classical Hodgkin lymphoma at diagnosis and relapse
| Autor: | Monika Szczepanowski, Antje Schnitter, Wolfram Klapper, Peter Möller, Katharina Reddemann, Christoph Thorns, Falko Fend, Rainer Spang, Birgit Federmann, Sarah Reinke, Christian W. Kohler |
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| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
Histology CD30 610 Medizin CD15 Hodgkin lymphoma Microenvironment PDL1 PD1 CD30 Pathology and Forensic Medicine 03 medical and health sciences 0302 clinical medicine Immunophenotyping immune system diseases hemic and lymphatic diseases Internal medicine Biopsy medicine 570 Biowissenschaften Biologie CD20 ddc:610 Hematology biology medicine.diagnostic_test business.industry 004 Informatik medicine.disease Lymphoma 030220 oncology & carcinogenesis biology.protein Cancer research Immunohistochemistry ddc:570 business 030215 immunology |
| Zdroj: | Journal of Hematopathology. 12:11-17 |
| ISSN: | 1865-5785 1868-9256 |
| DOI: | 10.1007/s12308-019-00350-2 |
| Popis: | Classical Hodgkin lymphoma is dominated by the non-neoplastic microenvironment, while the neoplastic Hodgkin-Reed-Sternberg cells compose only a minority of cells in the lymphoma tissue. Both the Hodgkin-Reed-Sternberg cells due to their expression of CD30 and PD-L1 and the microenvironment with abundant T cells and expression of PD1 are specifically targeted by new treatment concepts. We aimed to understand the dynamics of therapeutic targets in patients treated with conventional chemotherapy. We analyzed sequential biopsy specimens obtained at diagnosis and at relapse from the same patient for morphology, immunophenotype, and microenvironmental components. The morphological subtype changed between primary and relapse biopsy in 20% of cases. The immunophenotype was stable with respect to CD30, CD3, and LMP1 but variable with respect to CD15 and CD20 expression. Gene expression revealed 8 upregulated and 20 downregulated genes at relapse (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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