Evolutionary changes in influenza B are not primarily governed by antibody selection
| Autor: | Gillian M. Air, R G Webster, A J Gibbs, W G Laver |
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| Rok vydání: | 1990 |
| Předmět: |
Genes
Viral Molecular Sequence Data Orthomyxoviridae Hemagglutinins Viral Hemagglutinin (influenza) Cross Reactions Antibodies Viral medicine.disease_cause H5N1 genetic structure Antigenic drift Influenza A virus medicine skin and connective tissue diseases Antigens Viral Phylogeny Multidisciplinary biology Influenzavirus B virus diseases Antigenic shift biology.organism_classification Biological Evolution Virology Influenza B virus biology.protein sense organs Neuraminidase Research Article |
| Zdroj: | Proceedings of the National Academy of Sciences. 87:3884-3888 |
| ISSN: | 1091-6490 0027-8424 |
| Popis: | Influenza B viruses evolve more slowly than human influenza A, but no reasons for the difference have been established. We have analyzed sequence changes in the hemagglutinin and neuraminidase of influenza B viruses (and have determined four hemagglutinin sequences, of B/Bonn/43, B/USSR/100/83, B/Victoria/3/85, and B/Memphis/6/86) in relation to antigenic properties and compared these with similar analyses of variation in influenza A antigens. Independent of the slower rate of change in influenza B antigens, only approximately 30% of nucleotide changes in either the hemagglutinin or neuraminidase gene sequence result in amino acid changes in the protein, whereas in influenza A 50% of nucleotide changes result in altered amino acids. Thus, there is less selection for change, or less tolerance to change, in the influenza B antigens. This is similar to findings with influenza C and findings with influenza A viruses that replicate in lower animals and birds and is closer to the type of variation found in other RNA viruses. We propose that human influenza A is unique in that it is the only virus group in which antibody selection dominates evolutionary change. |
| Databáze: | OpenAIRE |
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