Encephalitis associated with positive anti-GluR antibodies showing abnormal appearance in basal ganglia, pulvinar and gray matter on MRI -Case report
| Autor: | Yukitoshi Takahashi, Tomoko Saito, Yosuke Kokunai, Harutoshi Fujimura, Saito Toshio |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
Pathology medicine.medical_specialty Central nervous system Pulvinar Receptors N-Methyl-D-Aspartate Basal Ganglia Cerebrospinal fluid Pregnancy Basal ganglia Humans Medicine Autoantibodies Lung biology medicine.diagnostic_test business.industry Brain Magnetic resonance imaging Puerperal Disorders medicine.disease Magnetic Resonance Imaging Virology medicine.anatomical_structure Methylprednisolone biology.protein Encephalitis Female Neurology (clinical) Antibody business medicine.drug |
| Zdroj: | Rinsho Shinkeigaku. 51:192-196 |
| ISSN: | 1882-0654 0009-918X |
| DOI: | 10.5692/clinicalneurol.51.192 |
| Popis: | We treated a 25-year-old woman with encephalitis. Following delivery, the patient developed fever, consciousness disturbance, cognitive dysfunction, and progressive motor dysfunction. In addition, mycobacterium tuberculosis was found in the lung, though there was no evidence of such infection in the central nervous system. Cerebrospinal fluid analysis revealed a slight elevation of mononuclear cells with a normal protein level indicating a possible viral infection. We could not find the origin of the infection, though the serum anti-glutamate epsilon2 receptor antibody was positive. Intravenous administration of methylprednisolone (1000 mg/day for 3 days) was temporarily effective for improvement of the clinical signs and symptoms. However, she finally demonstrated rapid deterioration resulting in death. Diffusion-weighted brain magnetic resonance imaging demonstrated abnormal high intensity lesions in the bilateral pulvinar and gray matter, with an abnormal appearance mimicking pulvinar sign. |
| Databáze: | OpenAIRE |
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