Vitamin D levels predict the response to cardiac resynchronization therapy in patients with systolic heart failure
| Autor: | Kudret Aytemir, Lale Tokgozoglu, Ali Oto, Adem Özkan, Hamza Sunman, N. Maharjan, Ergun Baris Kaya, Asuman Özkara, Serkan Asil, Uğur Canpolat, Tülin Bayrak, Hikmet Yorgun |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Male
medicine.medical_specialty lcsh:Internal medicine lcsh:Diseases of the circulatory (Cardiovascular) system medicine.drug_class Systole medicine.medical_treatment Cardiac resynchronization therapy cardiac resynchronization therapy heart failure lcsh:Medicine 030204 cardiovascular system & hematology 03 medical and health sciences QRS complex 0302 clinical medicine Heart Conduction System Predictive Value of Tests Internal medicine Vitamin D and neurology Natriuretic peptide Medicine Humans cardiovascular diseases Vitamin D lcsh:RC31-1245 Ischemic cardiomyopathy Ejection fraction business.industry lcsh:R vitamin d Odds ratio Middle Aged medicine.disease Treatment Outcome lcsh:RC666-701 030220 oncology & carcinogenesis Heart failure Cardiology cardiovascular system Female Cardiology and Cardiovascular Medicine business Biomarkers |
| Zdroj: | Türk Kardiyoloji Derneği Arşivi, Vol 44, Iss 8, Pp 670-676 (2016) |
| ISSN: | 1016-5169 |
| Popis: | Objective: The aim of this study was to examine the relationship between vitamin D levels in patients with heart failure (HF) and response to cardiac resynchronization therapy (CRT). Methods: We studied 57 patients (mean age: 60.47+-13.09 years) with New York Heart Association Class II or III heart failure, QRS duration ≥120 milliseconds, and ejection fraction 15% decrease in left ventricular end-systolic volume at 6 months compared with baseline measurements. Vitamin D levels were evaluated before CRT implantation with ELISA. Results: Of the 57 patients, 34 patients (59.6%) were classified as responders and 23 patients (40.4%) were classified as non-responders. Baseline features, laboratory findings, and echocardiographic characteristics were nearly the same in both groups. High vitamin D level was detected in responder group compared to non-responder group (26.17+-7.5 vs 21.15+-5.9; p=0.009). Age, hypertension, diabetes mellitus, ischemic cardiomyopathy, QRS morphology and duration, and levels of B-type natriuretic peptide (BNP) and vitamin D were associated with CRT response in our study population. In multivariate regression analysis, preimplantation QRS duration, and BNP and vitamin D levels remained independent predictors (QRS duration Odds ratio [OR]: 1.047, CI: 1.019–1.417, p=0.006; BNP OR: 0.997, 95% CI: 0.994–0.999, p=0.029; vitamin D OR: 1.121, 95% CI: 1.011–1.242, p=0.030). Conclusion: In the present study, preimplantation level of vitamin D was found to be predictor of response to CRT, independent of BNP. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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