Supplementary Figures 1 - 5, Table 1 from The Niacin/Butyrate Receptor GPR109A Suppresses Mammary Tumorigenesis by Inhibiting Cell Survival

Autor: Muthusamy Thangaraju, Vadivel Ganapathy, Puttur D. Prasad, Lesleyann Hawthorn, Pamela M. Martin, Nagendra Singh, Ling Lan, Ravi N. Padia, Sudha Ananth, Sabarish Ramachandran, Rajneesh Pathania, Selvakumar Elangovan
Rok vydání: 2023
DOI: 10.1158/0008-5472.22402472.v1
Popis: PDF file - 548K, Supplementary Table S1- Primers used for the RT-PCR assays. Figure S1. DNA methylation inhibitor re-activates GPR109A expression in human breast cancer cells. Figure S2. Stable expression of GPR109A in human breast cancer cell lines. Figure S3. GPR109A activation in breast cancer cells inhibits anti-apoptotic genes and induces pro-apoptotic genes. Figure S4. GPR109A activation in breast cancer cells regulates genes involved in various cellular processes. Figure S5. GPR109A binding is inhibited by components in the media. A, MB231-pCDH and MB231-GPR109A stable cell lines were subjected to radio-labeled nicotinate (NA) binding with binding buffer and L15 media.
Databáze: OpenAIRE