HLA-DR antigens and HLA-DQ beta chain polymorphism in susceptibility to rheumatoid arthritis
| Autor: | Helena Reijonen, I Jokinen, Pekka Hannonen, H Arvilommi, J Ilonen, Timo Möttönen |
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| Rok vydání: | 1990 |
| Předmět: |
Autoimmune disease
Immunology HLA-DR Antigens Immunogenetics Biology medicine.disease General Biochemistry Genetics and Molecular Biology Arthritis Rheumatoid Rheumatology Antigen HLA-DQ Antigens Rheumatoid arthritis HLA-DQ medicine Humans Immunology and Allergy Genetic Predisposition to Disease Restriction fragment length polymorphism Allele Polymorphism Restriction Fragment Length HLA-DR Antigen Research Article |
| Zdroj: | Annals of the Rheumatic Diseases. 49:494-496 |
| ISSN: | 0003-4967 |
| Popis: | Forty four patients with rheumatoid arthritis (RA) were studied for HLA-DR antigens and for HLA-DQ beta chain gene restriction fragment length polymorphism using DNA hybridisation. A significant increase in the prevalence of the DR4 antigen and a tendency towards an increase of DR1 was found in patients with RA. No allelic form of HLA-DQ restriction fragment length polymorphism patterns was increased, but the prevalence of an allele characterised by a combination of 7.5 and 3 kb fragments was decreased among patients with RA. The DQw8 subtype represented by a 12 kb fragment was the most common DR4 associated allele, and a 3.7 kb fragment related to DQw7 was found in only 5/25 (20%) DR4 positive patients and 2/12 (17%) controls. The results support the hypothesis that RA susceptibility factors are primarily located within HLA-DR genes but HLA-DQ genes may have a role in protection from the disease. |
| Databáze: | OpenAIRE |
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