IgA Plasma Cell Infiltration of Proximal Respiratory Tract, Pancreas, Kidney, and Coronary Artery in Acute Kawasaki Disease
| Autor: | Anne H. Rowley, Mitra B. Kalelkar, Laura S. Finn, Masaru Terai, Susan E. Crawford, Carlos A. Galliani, Shiro Naoe, Kei Takahashi, Carrie A. Mask, Stanford T. Shulman, Susan C. Baker |
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| Rok vydání: | 2000 |
| Předmět: |
Male
Immunoglobulin A Pathology medicine.medical_specialty Plasma Cells Respiratory System Mucocutaneous Lymph Node Syndrome Kidney Pathogenesis Japan Cause of Death Ethnicity medicine Humans Immunology and Allergy Precordial catch syndrome Respiratory system Child Pancreas biology Vascular disease business.industry Infant medicine.disease Coronary Vessels United States Infectious Diseases medicine.anatomical_structure Child Preschool Acute Disease biology.protein Female Kawasaki disease business Respiratory tract |
| Zdroj: | The Journal of Infectious Diseases. 182:1183-1191 |
| ISSN: | 1537-6613 0022-1899 |
| DOI: | 10.1086/315832 |
| Popis: | The etiology and pathogenesis of Kawasaki disease (KD) remain unknown. As previously reported, in US patients with acute KD, IgA plasma cells (PCs) infiltrate the vascular wall. To determine whether IgA PCs are increased at mucosal sites in KD and to determine whether other nonvascular KD tissues are infiltrated by IgA PCs, the cells were immunolocalized and quantitated in tissue sections taken from 18 US and Japanese patients who died of acute KD and from 10 age-matched controls. IgA PCs were significantly increased in the trachea of patients who died of acute KD, compared with controls (P |
| Databáze: | OpenAIRE |
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