Increased nitric oxide stress is associated with migraine
| Autor: | Günter Fauler, M. Truschnig-Wilders, Franz Fazekas, Anita Lechner, Höbarth G, S. Weiss, W. Renner, Renate Horejsi, Hans-Jürgen Gruber, Claudia Bernecker, M Wallner-Blazek, Andreas Meinitzer |
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| Rok vydání: | 2009 |
| Předmět: |
Adult
Male medicine.medical_specialty Arginine Nitric Oxide Synthase Type III Migraine with Aura Nitric Oxide Synthase Type II Nitric Oxide Nitric oxide Amidohydrolases chemistry.chemical_compound Enos Risk Factors Stress Physiological Internal medicine Citrulline Medicine Humans Nitrite Nitrites Aged Nitrates Polymorphism Genetic biology business.industry General Medicine biology.organism_classification medicine.disease Nitric oxide synthase Endocrinology chemistry Migraine Anesthesia biology.protein Female Neurology (clinical) business Asymmetric dimethylarginine |
| Zdroj: | Cephalalgia : an international journal of headache. 30(4) |
| ISSN: | 1468-2982 |
| Popis: | Nitric oxide (NO) has been implicated in migraine attacks, but the role of NO in migraine remains unclear. We here hypothesize that increased NO in the headache-free period is associated with migraine. One hundred and thirty probands participated in this study. Various parameters of the NO pathway, such as nitrate, nitrite, arginine, citrulline, nitrosylated proteins, asymmetric dimethylarginine, symmetrical dimethylarginine, expression of endothelial nitric oxide synthase (eNOS) and inducible nitric oxide synthase and two polymorphisms of eNOS were investigated. We found significant increased nitrate and decreased nitrite levels in migraineurs in the headache-free period. Nitrate and nitrite levels showed a significant inverse correlation. Logistic regression revealed an odds ratio of 3.6 for migraine. Other parameters of the NO pathway were neither altered in migraineurs nor correlated with nitrate. We show here that migraine patients suffer under sustained increased nitrosative stress in the headache-free period, which is associated with a 3.6-fold higher risk for migraine. |
| Databáze: | OpenAIRE |
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