Effects of the circadian rhythm of corticosteroids on leukocyte-endothelium interactions in the AM and PM
| Autor: | Walter F. Koscienski, Roberta L. Moldow, Christian W. Rocholl, Steven D. House, Stacey Ruch |
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| Rok vydání: | 1997 |
| Předmět: |
Male
medicine.medical_specialty Surgical stress Hydrocortisone Endothelium Neutrophils Hemodynamics Inflammation Biology Methylprednisolone General Biochemistry Genetics and Molecular Biology Microcirculation chemistry.chemical_compound Corticosterone Internal medicine Cell Adhesion medicine Animals Circadian rhythm Rats Wistar General Pharmacology Toxicology and Pharmaceutics Adrenalectomy General Medicine Circadian Rhythm Rats N-Formylmethionine Leucyl-Phenylalanine medicine.anatomical_structure Endocrinology chemistry Endothelium Vascular medicine.symptom Glucocorticoid medicine.drug |
| Zdroj: | Life Sciences. 60:2023-2034 |
| ISSN: | 0024-3205 |
| DOI: | 10.1016/s0024-3205(97)00167-7 |
| Popis: | Circadian rhythms are responsible for a number of key cycles within the body. In vivo microscopy was used to investigate the hypothesis that the circadian rhythm of corticosterone in rats produces different leukocyte-endothelium interactions throughout the day. The data indicate that corticosterone levels range from 12 ng ml in the AM to 260 ng ml in the PM. In contrast, the number of circulating polymorphonuclear leukocytes (PMNs) yields peak values in the AM (630 PMNs/μl) and trough values in the PM (262 PMNs/μl). During surgical stress there is a significant increase in the number of circulating PMNs in the PM but little change in the AM. Furthermore, there is significantly greater leukocyte-endothelium adhesion in the PM (5.2 cells/100 μm) than in the AM (2.9 cells/100 μm). Addition of the chemoattractant FMLP increased adhesion 125% in the AM but only 62% in PM. Both exogenous glucocorticoid supplementation for 2 weeks and bilateral adrenalectomy abolished the circadian rhythms of circulating PMNs, the number of sticking white blood cells and the initial stages of an acute inflammatory response. These findings suggest that the circadian rhythm of corticosterone alters leukocyte-endothelium interactions throughout the day. |
| Databáze: | OpenAIRE |
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