BCG masking phenomena might depend on the species of Mycobacterium
| Autor: | Saulius Caplinskas, Mykolas Mauricas, Pavel Korabliov, Gintautas Vysniauskis, Joanna Chorostowska-Wynimko, Irena Dumalakiene, Rita Viliene, Ginreta Magelinskiene, Arunas Valiulis, Joana Korablioviene, Justinas Baleisis |
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| Rok vydání: | 2021 |
| Předmět: |
0303 health sciences
Mycobacterium bovis General Immunology and Microbiology biology 030306 microbiology Wild type General Medicine biology.organism_classification Microbiology 03 medical and health sciences 0302 clinical medicine Immune system medicine.anatomical_structure Antigen medicine 030212 general & internal medicine BCG vaccine Sensitization Mycobacterium terrae Mycobacterium |
| Zdroj: | Acta Microbiologica et Immunologica Hungarica. 68:27-33 |
| ISSN: | 1588-2640 1217-8950 |
| Popis: | This study investigated BCG masking dependency on the species of Mycobacterium through the immune response to the mycobacterial region of deletion 1 (RD-1) associated growth affecting proteins (GEP).To evaluate the effects of GEP, 8-week old female BALB/c mice were immunized with either the wild type Mycobacterium bovis (MBGEP) or the ATCC Mycobacterium avium subsp. avium (MAGEP) strain and then subjected to further exposure with Mycobacterium terrae or M. avium sub. avium. Mice immunized with MAGEP and those mice further exposed to M. avium subsp. avium had increased granulocytes (GRA) and monocytes to lymphocytes rate (MLR) compared to control mice. Immunization of mice with GEP induced an antibody response one month after primary immunization, as observed by cross-reactivity. Our findings suggest that MAGEP is related to a latent hypersensitivity reaction and an increased risk of mycobacterial infection susceptibility. According to the results of the present study, previous sensitization with NTM antigens results in varying immune reactions after contact with different NTM argued that masking phenomena may be dependent on the species of Mycobacterium. |
| Databáze: | OpenAIRE |
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