A non-invasive method for the in vivo determination of skin antioxidant capacity (IAC-S�)
| Autor: | Nicola Solaroli, Silvia Vertuani, Stefano Manfredini, Paola Ziosi, Elena Besco |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Adult
Luminescence Antioxidant media_common.quotation_subject medicine.medical_treatment Tocopherols Dermatology Oxidative phosphorylation Dermanalyzer® Photochemiluminescence Skin antioxidant capacity Tocopherol Pharmacology medicine.disease_cause Cosmetics Antioxidants Ingredient Double-Blind Method In vivo Image Processing Computer-Assisted medicine Humans Surgical Tape media_common business.industry Pruritus Nicotinic Acids Forearm Antioxidant capacity Biochemistry Erythema Epidermis business Oxidative stress |
| Zdroj: | Skin Research and Technology. 12:303-308 |
| ISSN: | 1600-0846 0909-752X |
| DOI: | 10.1111/j.0909-752x.2006.00189.x |
| Popis: | BACKGROUND/PURPOSES Skin antioxidant network protects cells against oxidative injury and prevents the production of oxidation products. When oxidative stress overwhelms the skin antioxidant capacity, the subsequent modification of the cellular redox apparatus leads to an alteration of cell homeostasis leading to degenerative processes. In the dermocosmetic field, the topical application of antioxidants is often suggested as a possible strategy to prevent and modulate oxidative skin damages. Continuing our studies addressed to set-up new bio-engineering protocols for the claim substantiation of antioxidant cosmetic products, we have developed a new non-invasive methodology for the evaluation of antioxidants cosmetics ingredients and finished products. METHODS The effects of a pre-treatment on forearm skin with an antioxidant ingredient were investigated on 15 volunteers, in a double-blind randomised fashion. A non-invasive method was devised that comprises the collection of forehead SC layers of the pre-treated area and control and the next evaluation of skin antioxidant capacity (IAC-S) by a luminescence-based method. RESULTS The results showed that the antioxidant preparation was able to increase, to a statistically significant extent (P |
| Databáze: | OpenAIRE |
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