Longitudinal evaluation of anthracycline cardiotoxicity by signal-averaged electrocardiography in children with cancer
| Autor: | Miho Maeda, Daichi Fukumi, Yohko Uchikoba, Shunichi Ogawa |
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| Rok vydání: | 2002 |
| Předmět: |
Male
medicine.medical_specialty Anthracycline Electrocardiography Internal medicine parasitic diseases medicine Humans Anthracyclines Longitudinal Studies Subclinical infection Cardiotoxicity medicine.diagnostic_test business.industry Cancer Signal Processing Computer-Assisted Precursor Cell Lymphoblastic Leukemia-Lymphoma medicine.disease Signal-averaged electrocardiography Leukemia Myeloid Acute Echocardiography Heart failure Pediatrics Perinatology and Child Health Toxicity Cardiology Electrocardiography Ambulatory Female business Cardiomyopathies |
| Zdroj: | Pediatrics international : official journal of the Japan Pediatric Society. 44(2) |
| ISSN: | 1328-8067 |
| Popis: | Background: The aim of the present study was to investigate the detection of anthracycline cardiotoxicity by signal-averaged electrocardiography (SAE) in children with cancer. Methods: There were 29 patients with a cumulative anthracycline (ATC) dose of 75−600 mg/m2. None of them had congestive heart failure. Patients underwent SAE just before (detection of chronic cardiotoxicity) and just after (detection of acute cardiotoxicity) ATC therapy. Echocardiography and Holter electrocardiography were performed at the same time. The rates of abnormal SAE, echocardiography, and electrocardiogram findings were calculated and compared for every 100 mg/m2 of ATC. Results: The SAE showed a significantly higher detection rate for acute cardiotoxicity was at a cumulative ATC dose of less than 400 mg/m2 when compared with other methods (P |
| Databáze: | OpenAIRE |
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