A new electrochemical platform based on low cost nanomaterials for sensitive detection of the amoxicillin antibiotic in different matrices
| Autor: | Fernando H. Cincotto, Maria Del Pilar Taboada Sotomayor, Fernando C. Moraes, Anderson Medeiros dos Santos, Ademar Wong, Orlando Fatibello-Filho |
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| Přispěvatelé: | Universidade Estadual Paulista (Unesp), Universidade Federal de São Carlos (UFSCar), Federal University of Rio de Janeiro |
| Rok vydání: | 2019 |
| Předmět: |
Real samples
Polymers New electrochemical sensor Printex 6L carbon Food Contamination 02 engineering and technology Electrochemistry 01 natural sciences Analytical Chemistry Nanomaterials Polystyrene sulfonate PSS [PEDOT] chemistry.chemical_compound Limit of Detection Quantum Dots Cadmium Compounds Animals Voltammetry Electrodes Detection limit Quantum dots Chemistry 010401 analytical chemistry Amoxicillin Repeatability Electrochemical Techniques 021001 nanoscience & nanotechnology Ascorbic acid Bridged Bicyclo Compounds Heterocyclic Carbon 0104 chemical sciences Anti-Bacterial Agents Milk Electrode Polystyrenes Tellurium 0210 nano-technology Nuclear chemistry |
| Zdroj: | Scopus Repositório Institucional da UNESP Universidade Estadual Paulista (UNESP) instacron:UNESP |
| ISSN: | 1873-3573 |
| Popis: | Made available in DSpace on 2020-12-12T01:39:10Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-01-01 Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) A new electrochemical device based on a combination of nanomaterials such as Printex 6L Carbon and cadmium telluride quantum dots within a poly(3,4-ethylenedioxythiophene) polystyrene sulfonate film was developed for sensitive determination of amoxicillin. The morphological, structural and electrochemical characteristics of the nanostructured material were evaluated using X-ray diffraction, confocal microscopy, transmission electron microscopy and voltammetric techniques. The synergy between these materials increased the electrochemical activity, the electron transfer rate and the electrode surface area, leading to a high magnitude of the anodic peak current for the determination of amoxicillin. The electrochemical determination of the antibiotic was carried out using square-wave voltammetry. Under the optimised experimental conditions, the proposed sensor showed high sensitivity, repeatability and stability to amoxicillin determination, with an analytical curve in the amoxicillin concentration range from 0.90 to 69 μmol L−1, and a low detection limit of 50 nmol L−1. No significant interference in the electrochemical signal of amoxicillin was observed from potential biological interferences and drugs widely used, such as uric acid, paracetamol, urea, ascorbic acid and caffeine. It was demonstrated that without any sample pre-treatment and using a simple measurement device, the sensor could be an alternative method for not only the analysis of pharmaceutical products (commercial tablets) and clinical samples (urine), but also to examine food quality (milk samples). Department of Analytical Chemistry Institute of Chemistry State University of São Paulo (UNESP) and National Institute for Alternative Technologies of Detection Toxicological Evaluation and Removal of Micropollutants and Radioactives (INCT-DATREM) Department of Chemistry Federal University of São Carlos, P. O. Box 676 Institute of Chemistry Federal University of Rio de Janeiro Department of Analytical Chemistry Institute of Chemistry State University of São Paulo (UNESP) and National Institute for Alternative Technologies of Detection Toxicological Evaluation and Removal of Micropollutants and Radioactives (INCT-DATREM) CNPq: 160150/2015-9 FAPESP: 2014/50945-4 FAPESP: 2016/16565-5 FAPESP: 2017/10118-0 CNPq: 306650/2016-9 CNPq: 405546/2018-1 CNPq: 429462/2018-2 |
| Databáze: | OpenAIRE |
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