Searching for new genes and loci involved in cleft lip and palate in the Polish population – genome-wide association study
| Autor: | Piotr Wójcicki, Barbara Biedziak, Anna Sowińska, Paweł P. Jagodziński, Kamil K. Hozyasz, Sylwia Matuszewska‑Trojan, Adrianna Mostowska, Joanna Wesoly |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Genetics business.industry Single-nucleotide polymorphism Genome-wide association study Polish population 03 medical and health sciences 030104 developmental biology Healthy individuals Genotype risk factors Medicine Family history polymorphisms business Genotyping Gene genome wide association study cleft lip and palate |
| Zdroj: | Wroclaw Medical University Journal of Medical Science, Vol 83, Iss 3 (2014) |
| ISSN: | 2353-9801 2353-9798 |
| DOI: | 10.20883/medical.78 |
| Popis: | The project “Searching for new genes and loci involved in cleft lip and palate in the Polish population – genome-wide association study” is a case-control study in a group of unrelated subjects with non-syndromic cleft lip with or without cleft palate (NSCL/P) and healthy individuals with no family history of clefting or other congenital disorders. The overall goal of this grant proposal is to identify novel genetic factors, which can play a significant role in the pathogenesis of orofacial clefts in the Polish population. To accomplish the proposed aim, a two stage genome-wide association study will be performed. In the first stage, Illumina's HumanOmni Express BeadChips arrays will be used to genotype over 700,000 polymorphisms in NSCL/P patients and controls. In the second stage, SNPs showing the most compelling association with the risk of orofacial clefts will be tested in an independent sample set using standard genotyping methods. This research project is expected to be completed in July 2015. |
| Databáze: | OpenAIRE |
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