Sustained dual release of ciprofloxacin and lidocaine from ionic exchange responding film based on alginate and hyaluronate for wound healing
| Autor: | Ana Lidia Apas, María Florencia Sanchez, Maria Laura Guzman, Fabiana L. Alovero, María Eugenia Olivera |
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| Rok vydání: | 2021 |
| Předmět: |
Staphylococcus aureus
Lidocaine Dual release Alginates medicine.drug_class medicine.medical_treatment Antibiotics Pharmaceutical Science Ionic bonding 02 engineering and technology Pharmacology 030226 pharmacology & pharmacy 03 medical and health sciences 0302 clinical medicine Ciprofloxacin medicine Saline Wound Healing integumentary system Chemistry 021001 nanoscience & nanotechnology Polyelectrolyte Anti-Bacterial Agents 0210 nano-technology Wound healing medicine.drug |
| Zdroj: | European Journal of Pharmaceutical Sciences. 161:105789 |
| ISSN: | 0928-0987 |
| Popis: | This study presents a new antibiotic-anesthetic film (AA-film) based on natural polyelectrolytes ionically complexed with lidocaine and ciprofloxacin to manage pain associated with infected wounds. The rational selection of the components resulted in the AA-films being transparent, compatible with wound skin pH and highly water vapor permeable. The drug release properties evaluated in saline solution and water revealed an ionic exchange mechanism for the release of both drugs and showed that ciprofloxacin acts as a cross-linker, as was confirmed by rheological evaluation. The in vitro antimicrobial efficacy against S. aureus and P. aeruginosa was demonstrated. Furthermore, AA-films exhibit a high fluid absorption capacity and act as a physical barrier for microorganisms. This work highlights the great potential of this smart system as an attractive dressing for skin wounds, surpassing currently available treatments. |
| Databáze: | OpenAIRE |
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