Assessment and validation of the internal gross tumour volume of gastroesophageal junction cancer during simultaneous integrated boost radiotherapy
| Autor: | Ning Li, Shunan Qi, Ningning Lu, Shulian Wang, Yu Tang, Yongwen Song, Yuan Tang, Wenyang Liu, Bo Chen, Yexiong Li, Jinming Shi, Jing Jin, Hui Fang, Yueping Liu |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
Simultaneous integrated boost
Adult Male medicine.medical_specialty Time Factors Gross tumour volume Esophageal Neoplasms medicine.medical_treatment R895-920 Gastroesophageal Junction Medical physics. Medical radiology. Nuclear medicine Text mining Stomach Neoplasms Gastroesophageal junction (GEJ) cancer Medicine Humans Radiology Nuclear Medicine and imaging RC254-282 Aged Simultaneous integrated boost radiotherapy Radiotherapy business.industry Research Cancer Neoplasms. Tumors. Oncology. Including cancer and carcinogens Middle Aged medicine.disease Tumor Burden Radiation therapy Oncology Female Radiology Esophagogastric Junction Neoadjuvant business Internal gross tumour volume |
| Zdroj: | Radiation Oncology, Vol 17, Iss 1, Pp 1-7 (2022) Radiation Oncology (London, England) |
| Popis: | Background Respiratory motion may introduce errors during radiotherapy. This study aims to assess and validate internal gross tumour volume (IGTV) margins in proximal and distal borders of gastroesophageal junction (GEJ) tumours during simultaneous integrated boost radiotherapy. Methods We enrolled 10 patients in group A and 9 patients in group B. For all patients, two markers were placed at the upper and lower borders of the tumour before treatment. In group A, within the simulation and every 5 fractions of radiotherapy, we used 4-dimensional computed tomography (4DCT) to record the intrafractional displacement of the proximal and distal markers. By fusing the average image of each repeated 4DCT with the simulation image based on the lumbar vertebra, the interfractional displacement could be obtained. We calculated the IGTV margin in the proximal and distal borders of the GEJ tumour. In group B, by referring to the simulation images and cone-beam computed tomography (CBCT) images, the range of tumour displacement in proximal and distal borders of GEJ tumour was estimated. We calculated the proportion of marker displacement range in group B lay within the IGTV margin calculated based on the data obtained in group A to estimate the accuracy of the IGTV margin. Results The intrafractional displacement in the cranial–caudal (CC) direction was significantly larger than that in the anterior–posterior (AP) and left–right (LR) directions for both the proximal and distal markers of the tumour. The interfractional displacement in the AP and LR directions was larger than that in the CC direction (p = 0.001, p = 0.017) based on the distal marker. The IGTV margins in the LR, AP and CC directions were 9 mm, 8.5 mm and 12.1 mm for the proximal marker and 15.8 mm, 12.7 mm and 11.5 mm for the distal marker, respectively. In group B, the proportions of markers that located within the IGTV margin in the LR, AP and CC directions were 96.5%, 91.3% and 96.5% for the proximal marker and 100%, 96.5%, 93.1% for the distal marker, respectively. Conclusions Our study proposed individualized IGTV margins for proximal and distal borders of GEJ tumours during neoadjuvant radiotherapy. The IGTV margin determined in this study was acceptable. This margin could be a reference in clinical practice. |
| Databáze: | OpenAIRE |
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