Anti-Inflammatory Activity of Dichloromethane Extract of Heterotheca inuloides in Vivo and in Vitro*
| Autor: | Salvador Cañigueral, Tomás Adzet, Therese Ringbom, Blanca Freixa, Lars Bohlin, Laura Segura, Roser Vila, Premila Perera |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
medicine.drug_class
Pharmaceutical Science Asteraceae Biology Pharmacognosy Anti-inflammatory Analytical Chemistry Mice In vivo Drug Discovery medicine Animals Humans Cyclooxygenase Inhibitors Croton oil Cells Cultured ED50 Pharmacology Traditional medicine Plant Extracts Anti-Inflammatory Agents Non-Steroidal Organic Chemistry Biological activity biology.organism_classification Croton In vitro Complementary and alternative medicine Molecular Medicine |
| Zdroj: | Planta Medica. 66:553-555 |
| ISSN: | 1439-0221 0032-0943 |
| DOI: | 10.1055/s-2000-8613 |
| Popis: | The dichloromethane extract from the dried flowers of Heterotheca inuloides Cass. was investigated on several pharmacological models of inflammation in vivo and in vitro. It showed anti-inflammatory activity on the croton oil-induced oedema test in mouse ear, at 1 mg/ear. The compound isolated from this extract, 7-hydroxy-3,4-dihydrocadalin, showed anti-inflammatory effect on the same experimental model (ED50 of 0.9 mumol/ear), as well as on COX-1 and COX-2 catalysed prostaglandin biosynthesis assays, with IC50 values of 22 microM and 526 microM, respectively. No effect was observed on carrageenan-induced oedema and on fMLP/PAF-induced exocytosis of human neutrophils. The COX-1 inhibitory effect showed by 7-hydroxy-3,4-dihydrocadalin might be related to the anti-inflammatory activity on the topical oedema induced by croton oil. |
| Databáze: | OpenAIRE |
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