Enhanced responsiveness ofα-noradrenergic receptors following discrete electrolytic lesions of the nucleus locus coeruleus: A behavioral demonstration
| Autor: | De Carvalho Lp, Zornetzer Sf |
|---|---|
| Rok vydání: | 1982 |
| Předmět: |
Male
medicine.medical_specialty Reserpine Apomorphine Alpha (ethology) Motor Activity Clonidine Mice Internal medicine medicine Animals Habituation Habituation Psychophysiologic Receptor Biological Psychiatry Chemistry Receptors Adrenergic alpha Receptors Adrenergic Psychiatry and Mental health medicine.anatomical_structure Endocrinology Neurology Catecholamine Locus coeruleus Locus Coeruleus Neurology (clinical) Nucleus medicine.drug |
| Zdroj: | Journal of Neural Transmission. 53:23-37 |
| ISSN: | 1435-1463 0300-9564 |
| DOI: | 10.1007/bf01243517 |
| Popis: | Locomotor activity was evaluated in groups of reserpine-treated mice administered the catecholamine receptor agonists apomorphine and clonidine. Pretreatment of selected groups of mice with discrete electrolytic destruction of the nucleus locus coeruleus (LC) resulted in a clonidine-potentiation of apomorphine-stimulated locomotor activity. This effect was greater in unilateral than bilateral lesioned mice. LC lesions also significantly reduced the level of locomotor habituation achieved within a 60 min observation period. The data are interpreted to suggest that discrete lesions of the nucleus LC results in increased alpha-noradrenergic receptor sensitivity. |
| Databáze: | OpenAIRE |
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