Nanocomposite foams based on flexible biobased thermoplastic polyurethane and ZnO nanoparticles as potential wound dressing materials
| Autor: | Mirela Serban, Sorina Dinescu, Aleksandra Bužarovska, Gratiela Gradisteanu Pircalabioru, Andreea D. Lazar, Luc Avérous, Marieta Costache, Chiara Gualandi |
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| Přispěvatelé: | Institut de chimie et procédés pour l'énergie, l'environnement et la santé (ICPEES), Université de Strasbourg (UNISTRA)-Matériaux et nanosciences d'Alsace (FMNGE), Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Buzarovska A., Dinescu S., Lazar A.D., Serban M., Pircalabioru G.G., Costache M., Gualandi C., Averous L. |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Materials science
Morphology (linguistics) Biocompatibility Scanning electron microscope Polymers Polyurethanes Thermoplastic polyurethane Bioengineering Biocompatible Materials 02 engineering and technology Microbial Sensitivity Tests 010402 general chemistry 01 natural sciences Nanocomposites Biomaterials X-Ray Diffraction Spectroscopy Fourier Transform Infrared Fourier transform infrared spectroscopy Cell Proliferation chemistry.chemical_classification Wound Healing Nanocomposite Bacteria Polymer 021001 nanoscience & nanotechnology Bandages 0104 chemical sciences Wound dressings [CHIM.POLY]Chemical Sciences/Polymers chemistry Polymerization Chemical engineering Mechanics of Materials Nanoparticles Nanocomposite foam Antibacterial activity Zinc Oxide 0210 nano-technology |
| Zdroj: | Materials Science and Engineering C Materials Science and Engineering C, 2019, 104, ⟨10.1016/j.msec.2019.109893⟩ |
| Popis: | In the present study biobased and soft thermoplastic polyurethane (TPU), obtained by polymerization from fatty acids, was used to produce TPU/ZnO nanocomposite foams by thermally induced phase separation method (TIPS). The produced foams were characterized and evaluated regarding their potential uses as wound dressing materials. The structure and morphology of the prepared flexible polymer foams with different content of ZnO nanofiller (1, 2, 5 and 10 wt% related to the polymer) were studied by Fourier transform infrared spectroscopy (FTIR) and Scanning electron microscopy (SEM). Highly porous nanocomposite structure made of interconnected pores with dimensions between 10 and 60 μm was created allowing water vapor transmission rate (WVTR) up to 8.9 mg/cm2·h. The TPU/ZnO foams, tested for their ability to support cells and their growth, showed highest cell proliferation for TPU nanocomposite foams with 2 and 5 wt% ZnO. Overall, the nanocomposite foams displayed a low cytotoxic potential (varied proportionally to the ZnO content) and good biocompatibility. All tested nanocomposite foams were found to be significantly active against biofilms formed by different Gram-positive (Enterococcus faecalis and Staphylococcus aureus) and Gram-negative (Escherichia coli and Pseudomonas aeruginosa) bacteria. Based on their behaviors, flexible TPU/ZnO nanocomposite foams can be considered for biomedical applications such as potential active wound dressing. |
| Databáze: | OpenAIRE |
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