Interactions between stimulants: effects on DRL performance and lethality in rats
| Autor: | Ron C. Michaelis, Pedro L. Huerta, Frank A. Holloway, David C. Bird |
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| Rok vydání: | 1987 |
| Předmět: |
Drug
Male Phenethylamine Reinforcement Schedule media_common.quotation_subject Clinical Biochemistry Phenylpropanolamine Pharmacology Toxicology Biochemistry Behavioral Neuroscience chemistry.chemical_compound Caffeine medicine Animals Drug Interactions Ephedrine Amphetamine Biological Psychiatry media_common Dose-Response Relationship Drug Rats Inbred Strains Drug interaction Rats Drug Combinations chemistry Conditioning Operant Lethality Psychology medicine.drug |
| Zdroj: | Pharmacology, biochemistry, and behavior. 27(2) |
| ISSN: | 0091-3057 |
| Popis: | The Controlled Substances Act of 1970 drastically reduced the supply of amphetamines available to the public. It also inadvertently prompted the emergence of a new drug industry, namely the marketing of caffeine/phenylethylamine combinations packaged to look like many of the previously available amphetamine preparations. The findings of one recent experimental study corroborate anecdotal evidence that the interoceptive “high” produced by these look-alike stimulants mimics that produced by amphetamine. The present study was designed to further characterize the behavioral effects of caffeine/phenylethylamine combinations. The present findings suggest that adding ephedrine and phenylpropanolamine to caffeine markedly enhances the disruption of DRL performance, as well as the lethality of the drug. In addition, different patterns of interactions were obtained between amphetamine and caffeine versus the caffeine/ephedrine/phenylpropanolamine combination. |
| Databáze: | OpenAIRE |
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