Optimisation of a novel glass-alginate hydrogel for the treatment of intracranial aneurysms
| Autor: | Caitríona Lally, Sarah Brady, Eoin K. Fox, O. M. Clarkin |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Materials science Polymers and Plastics Alginates Organic Chemistry technology industry and agriculture Hydrogels Intracranial Aneurysm macromolecular substances 02 engineering and technology 021001 nanoscience & nanotechnology complex mixtures Embolization Therapeutic Molecular Weight 03 medical and health sciences 030104 developmental biology Compressive strength Aneurysm treatment Materials Chemistry Alginate hydrogel Glass 0210 nano-technology Biomedical engineering Gamma irradiation |
| Zdroj: | Carbohydrate polymers. 176 |
| ISSN: | 1879-1344 |
| Popis: | The current gold standard for aneurysm treatment is endovascular coiling. However, recurrence is observed in over 20% of cases. A novel hydrogel has been developed to treat aneurysms. This hydrogel is composed of a polymeric alginate, a novel ion releasing glass and glucono-delta-lactone. This is an internally setting alginate hydrogel, wherein the setting rate can be controlled by both the glass and the alginate chemistry. The aim of this work is to examine the effect of each component of the hydrogel and optimise the composition of the hydrogel, specifically the alginate molecular weight, M/G ratio and concentration. The effects of gamma sterilisation will also be examined. The results show that alginate concentration, chemical composition and molecular weight affect the compressive strength, working time, hardening time and deliverability of the hydrogel. Gamma irradiation of the alginate reduces the molecular weight, which has a negative effect on the usability of this hydrogel. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect