FIV induced encephalopathy: early brain lesions in the absence of viral replication in monocyte/macrophages. A pathogenetic model
| Autor: | Giuseppe Piedimonte, Mauro Magnan, Giorgio Brandi, Mauro Bendinelli, Attilio Corradi, Lucia Silvotti, Aderville Cabassi |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
viruses
Immunology Encephalopathy Immunodeficiency Virus Feline Cat Diseases Virus Replication Monocytes medicine Animals Monocytes macrophages Viral transport Cells Cultured Brain Diseases General Veterinary business.industry Macrophages medicine.disease Virology Disease Models Animal Viral replication Acute Disease Cats Lentivirus Infections Macrophages Peritoneal Brain lesions Neuropathogenesis business |
| Zdroj: | Veterinary Immunology and Immunopathology. 55:263-271 |
| ISSN: | 0165-2427 |
| DOI: | 10.1016/s0165-2427(96)05617-6 |
| Popis: | FIV induced encephalopathy represents a model for the study of the neuropathogenesis of AIDS. It has yet to be determined whether massive viral replication is a prerequisite for the development of early brain lesions. Using a drug delivery system developed by us, we have shown that early encephalic lesions appear in FIV infected subjects even when viral transport within the brain has been markedly reduced or blocked. |
| Databáze: | OpenAIRE |
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