Active fixation leads--long-term threshold reduction using a drug-infused ceramic collar
| Autor: | Michael Ng, Deirdre Harman, Michael Skalsky, Neil Anderson, Alison Tunstell, Ranjini Mathivanar |
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| Rok vydání: | 1991 |
| Předmět: |
medicine.medical_specialty
Ceramics Pacemaker Artificial medicine.medical_treatment Stimulation Dexamethasone Collar Low energy Internal medicine Aluminum Oxide Medicine Animals Ventricular Function Lead (electronics) Reduction (orthopedic surgery) Fixation (histology) Sheep business.industry Cardiac Pacing Artificial General Medicine Equipment Design Atrial Function Surgery Porous ceramics Electrodes Implanted Evaluation Studies as Topic Cardiology Cardiology and Cardiovascular Medicine business geographic locations Active fixation |
| Zdroj: | Pacing and clinical electrophysiology : PACE. 14(11 Pt 2) |
| ISSN: | 0147-8389 |
| Popis: | Previous investigators, including our group, have reported the threshold reduction benefits of steroid-releasing leads. To date, all published literature has been for the passive fixation versions. The application of steroids should also enhance the performance of active fixation leads. We have developed and tested an atrial and a ventricular Accufix lead with a dexamethasone acetate-releasing, porous ceramic collar (DA DEC). A long-term sheep study has shown a significant reduction in thresholds (THR) when compared to standard Accufix leads without the collar (ACC) for atrial (ATR) and ventricular (VENT) versions (bipolar THR [0.5 msec] at 24 weeks: VENT DA DEC = 0.51 +/- 0.07, VENT ACC = 1.49 +/- 1.03; ATR DA DEC = 1.31 +/- 1.14, ATR ACC = 2.99 +/- 1.31). All other parameters tested, including pacing and sensing impedance as well as polarization overpotential, were similar for the two groups. The Accufix DEC leads therefore have excellent potential for low energy stimulation. |
| Databáze: | OpenAIRE |
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