Protection against cadmium-induced limb malformations by pretreatment with cadmium or mercury
| Autor: | Vergil H. Ferm, W. M. Layton |
|---|---|
| Rok vydání: | 1980 |
| Předmět: |
Embryology
medicine.medical_specialty Health Toxicology and Mutagenesis Cadmium sulfate CADMIUM TOXICITY Limb Deformities Congenital chemistry.chemical_element Mice Inbred Strains Toxicology Mice chemistry.chemical_compound Pregnancy Internal medicine medicine Animals Metallothionein Cadmium Abnormalities Drug-Induced Mercuric acetate Extremities Mercury medicine.disease Mercury (element) Mice Inbred C57BL Endocrinology chemistry Gestation Female Developmental Biology |
| Zdroj: | Teratology. 21:357-360 |
| ISSN: | 1096-9926 0040-3709 |
| DOI: | 10.1002/tera.1420210312 |
| Popis: | Administration of 12 μmol/kg of cadmium sulfate ip to C57BL/6J mice within 3 weeks prior to pregnancy significantly reduced the incidence of limb malformations induced by 6 μrnol/kg of cadmium sulfate given ip on day 9 of pregnancy. In another experiment it was shown that administration of 6 μmol/kg or 12 μmol/kg of mercuric acetate on day 6 of gestation significantly reduced the incidence of limb malformations induced by 6 μmol/kg of cadmium given on day 9. It is postulated that this protective effect is due to the induction of increased maternal synthesis of a metal binding protein, probably metallothionein. This effect may be important in the design and interpretation of teratogenicity tests and in the evaluation of teratogenic risks to human populations chronically exposed to metals. |
| Databáze: | OpenAIRE |
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