Predictions of Pathological Features and Recurrence Based on FDG-PET Findings of Esophageal Squamous Cell Carcinoma after Trimodal Therapy
| Autor: | Yuta Ibuki, Yoichi Hamai, Toru Yoshikawa, Ikuno Nishibuchi, Morihito Okada, Yasushi Nagata, Yuji Murakami, Manabu Emi, Manato Ohsawa, Takaoki Furukawa, Tomoaki Kurokawa |
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| Rok vydání: | 2020 |
| Předmět: |
Oncology
medicine.medical_specialty Esophageal Neoplasms Lymphovascular invasion medicine.medical_treatment 03 medical and health sciences 0302 clinical medicine Fluorodeoxyglucose F18 Predictive Value of Tests Surgical oncology Internal medicine medicine Humans Pathological Neoadjuvant therapy business.industry Hazard ratio Chemoradiotherapy Neoadjuvant Therapy Confidence interval Positron-Emission Tomography 030220 oncology & carcinogenesis Predictive value of tests 030211 gastroenterology & hepatology Surgery Esophageal Squamous Cell Carcinoma Neoplasm Recurrence Local Radiopharmaceuticals business |
| Zdroj: | Annals of Surgical Oncology. 27:4422-4430 |
| ISSN: | 1534-4681 1068-9265 |
| Popis: | The degree of metabolic activity in tumor cells can be determined by 18F-fluorodeoxyglucose-positron emission tomography (FDG-PET). Associations between FDG uptake by primary tumors of locally advanced esophageal squamous cell carcinoma (ESCC) under trimodal therapy and the pathological features of such tumors have not been fully investigated. We evaluated relationships between the maximal standardized uptake (SUVmax) in primary tumors on preoperative PET images and pathological features as well as cancer recurrence in 143 patients with ESCC who underwent neoadjuvant chemoradiotherapy (NCRT) followed by surgery. The post-SUVmax significantly differed after NCRT for ypT and ypN status, lymphatic invasion (LI), venous invasion (VI), and recurrence. Furthermore, the %ΔSUVmax (rate of decrease between before and after NCRT) for LI, VI, and recurrence significantly differed. Univariate and multivariate analyses selected post-SUVmax and %ΔSUVmax as independent preoperative predictors of recurrence-free survival [hazard ratio (HR) 1.46; 95% confidence interval (CI) 1.24–1.72 and HR 0.97; 95% CI 0.96–0.99, respectively; p |
| Databáze: | OpenAIRE |
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