Rate and Characteristics of Incompletely Excised Cutaneous Squamous Cell Carcinoma: A Dermatological Daily Practice Multicenter Prospective Cohort Study

Autor: van Lee, Charlotte B, Kouloubis, Nina, Wakkee, Marlies, Kelleners-Smeets, Nicole W J, Nellen, Ruud G L, van Rengen, Annik, de Vijlder, Hanke C, Wijne, Leon C C, Nijsten, Tamar, van den Bos, Renate R
Přispěvatelé: Dermatology, RS: GROW - R3 - Innovative Cancer Diagnostics & Therapy, MUMC+: MA AIOS Dermatologie (9), Dermatologie, MUMC+: MA Dermatologie (9)
Rok vydání: 2022
Předmět:
Zdroj: Dermatologic Surgery, 48(12), 1269-1273. Lippincott Williams & Wilkins
Dermatologic Surgery, 48(12), 1269-1273. LIPPINCOTT WILLIAMS & WILKINS
ISSN: 1524-4725
1076-0512
DOI: 10.1097/dss.0000000000003606
Popis: BACKGROUND: Incomplete excision of squamous cell carcinoma (cSCC) is associated with an increased risk of recurrence, metastasis, and mortality.OBJECTIVE: To determine the rate and characteristics of incompletely excised cSCC in a dermatological daily practice setting.METHODS: Prospective study of all patients who gave informed consent, with a cSCC treated with standard excision (SE) at 1 of 6 Departments of Dermatology in the Netherlands between 2015 and 2017. Pathological reports were screened to detect all incompletely excised cSCCs.RESULTS: A total of 592 patients with 679 cSCCs were included, whereby most cases were low risk cSCC (89%). The rate of incompletely excised cSCC was 4% (n = 26), and the majority were high-risk cSCCs of which 24 invaded the deep excision margin.CONCLUSION: This prospective study showed that in a dermatological setting, the risk of an incompletely excised cSCC is low (4%) for a cohort that was dominated by low-risk cSCCs. Most incompletely excised cSCCs were of high risk, and incompleteness was almost always at the deep margins. These results suggest that for high-risk cSCC, one should pay attention especially to the deep margin when performing SE, and/or microscopic surgery should be considered.
Databáze: OpenAIRE
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