Anti-tumour therapeutic efficacy of OX40L in murine tumour model
| Autor: | Claire Entwisle, Esther Choolun, Shahid Mian, Stephanie E. B. McArdle, Cornelia S. McLean, Robert C. Rees, Murrium Ahmad, Geng Li, June Lynam, Peter T. Loudon, Selman A. Ali |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
CD4-Positive T-Lymphocytes
medicine.medical_treatment T cell Antineoplastic Agents OX40 Ligand CD8-Positive T-Lymphocytes Biology Cancer Vaccines Cell Line Mice Cancer immunotherapy Cell Line Tumor medicine Splenocyte Animals Simplexvirus Cytotoxic T cell Mice Inbred BALB C Membrane Glycoproteins General Veterinary General Immunology and Microbiology Public Health Environmental and Occupational Health Granulocyte-Macrophage Colony-Stimulating Factor Neoplasms Experimental Immunotherapy Fusion protein Infectious Diseases medicine.anatomical_structure Tumor Necrosis Factors Immunology Systemic administration Cancer research Molecular Medicine Female Cell Division Injections Intraperitoneal Neoplasm Transplantation Spleen CD8 T-Lymphocytes Cytotoxic |
| Zdroj: | Vaccine. 22:3585-3594 |
| ISSN: | 0264-410X |
| DOI: | 10.1016/j.vaccine.2004.03.041 |
| Popis: | OX40 ligand (OX40L), a member of TNF superfamily, is a co-stimulatory molecule involved in T cell activation. Systemic administration of mOX40L fusion protein significantly inhibited the growth of experimental lung metastasis and subcutaneous (s.c.) established colon (CT26) and breast (4T1) carcinomas. Vaccination with OX40L was significantly enhanced by combination treatment with intra-tumour injection of a disabled infectious single cycle-herpes simplex virus (DISC-HSV) vector encoding murine granulocyte macrophage-colony stimulating factor (mGM-CSF). Tumour rejection in response to OX40L therapy required functional CD4+ and CD8+ T cells and correlated with splenocyte cytotoxic T lymphocytes (CTLs) activity against the AH-1 gp70 peptide of the tumour associated antigen expressed by CT26 cells. These results demonstrate the potential role of the OX40L in cancer immunotherapy. |
| Databáze: | OpenAIRE |
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