Tissue engineering tools for modulation of the immune response
| Autor: | Ryan M. Boehler, Lonnie D. Shea, John G. Graham |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Cell Transplantation
Cell Culture Techniques Biocompatible Materials Adaptive Immunity Biology Regenerative Medicine Regenerative medicine Article General Biochemistry Genetics and Molecular Biology Immunomodulation Immune system Tissue engineering Antigen Humans Immunologic Factors Progenitor cell Inflammation Tissue Engineering Tissue Scaffolds Stem Cells Regeneration (biology) Gene Transfer Techniques biochemical phenomena metabolism and nutrition Acquired immune system Immunity Innate Transplantation Immunology Cytokines bacteria Neuroscience Biotechnology |
| Zdroj: | BioTechniques. 51:239-254 |
| ISSN: | 1940-9818 0736-6205 |
| Popis: | Tissue engineering scaffolds have emerged as a powerful tool within regenerative medicine. These materials are being designed to create environments that promote regeneration through a combination of: (i) scaffold architecture, (ii) the use of scaffolds as vehicles for transplanting progenitor cells, and/or (iii) localized delivery of inductive factors or genes encoding for these inductive factors. This review describes the techniques associated with each of these components. Additionally, the immune response is increasingly recognized as a factor influencing regeneration. The immune reaction to an implant begins with an acute response to the injury and innate recognition of foreign materials, with the subsequent chronic immune response involving specific recognition of antigens (e.g., transplanted cells) by the adaptive immune response, which can eventually lead to rejection of the implant. Thus, we also describe the impact of each component on the immune response, and strategies (e.g., material design, anti-inflammatory cytokine delivery, and immune cell recruitment/transplantation) to modulate, yet not eliminate, the local immune response in order to promote regeneration, which represents another important tool for regenerative medicine. |
| Databáze: | OpenAIRE |
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