RNA-mediated RNA degradation in transgene- and virus-induced gene silencing
| Autor: | Michael Metzlaff |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Small RNA
RNA-induced transcriptional silencing Transcription Genetic RNA-induced silencing complex Clinical Biochemistry Trans-acting siRNA Biology Virus Replication Biochemistry RNA interference Viral Interference Animals Gene Silencing Transgenes RNA Processing Post-Transcriptional Molecular Biology RNA Double-Stranded Fungi RNA Plants Plants Genetically Modified Cell biology RNA silencing Viruses biology.protein Dicer |
| Zdroj: | Biological chemistry. 383(10) |
| ISSN: | 1431-6730 |
| Popis: | In the 'RNA world' hypothesis it is postulated that RNA was the first genetic molecule. Recent discoveries in gene silencing research on plants, fungi and animals show that RNA indeed plays a key role not only in controlling invading nucleic acids, like viruses and transposable elements, but also in regulating the expression of transgenes and endogenous genes. Double-stranded RNAs were identified to be the triggering structures for the induction of a specific and highly efficient RNA silencing system, in which enzyme complexes, like Dicer and RISC, facilitate as 'molecular machines' the processing of dsRNA into characteristic small RNA species. RNA silencing can be transmitted rapidly from silenced to non-silenced cells by short and long distance signaling. There is evidence that at least one component of the signal is a specific, degradation-resistant RNA. |
| Databáze: | OpenAIRE |
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