Intrauterine repair of surgically created defects in mice (lip incision model) with a microclip: preamble to endoscopic intrauterine surgery
| Autor: | Wolff M. Kirsch, Kerby C. Oberg, Robert A. Hardesty, Norman Peckham, Michele L. Evans, T. T. Nguyen |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Giant Cells
Foreign-Body medicine.medical_specialty Microsurgery Time Factors medicine.medical_treatment Cleft Lip Dermatologic Surgical Procedures Fetoscopy Cleft lip repair 03 medical and health sciences Mice 0302 clinical medicine Fetus Suture (anatomy) Pregnancy Intrauterine surgery medicine Animals 030223 otorhinolaryngology Skin Endoscopes Inflammation Wound Healing medicine.diagnostic_test Collagen accumulation Fetal surgery business.industry Suture Techniques Endoscopy 030206 dentistry Lip Surgery Disease Models Animal Otorhinolaryngology Leukocytes Mononuclear Female Collagen Oral Surgery Wound healing business |
| Zdroj: | The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association. 32(2) |
| ISSN: | 1055-6656 |
| Popis: | We compared the difference between a nonpenetrating silver microclip and suture on wound healing, inflammatory response, and application time in the repair of surgically created standardized unilateral cleft lip type defects in fetal mice. Excellent lip continuity and dermal reconstitution were achieved by both methods of repair. Furthermore, collagen accumulation did not occur. Occasional mononuclear cells were seen around sutured repairs in contrast to microclipped repairs. The most significant difference, however, was in application time with the microclip requiring an average of 7 seconds (±2) compared to 90 seconds (±15) for suture. We conclude that the microclip offers distinct advantages for Intrauterine cleft lip repair: (1) nonpenetrating tissue approximation; (2) less inflammatory response than suture; (3) technically more rapid and less difficult to apply than suture; and (4) can be utilized more readily than suture for endoscopic approaches limiting the risks of fetal surgery for both the mother and the fetus. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|