Identification and characterization of pDC-like cells in normal mouse skin and melanomas treated with imiquimod
| Autor: | Petra Lührs, Simone Meindl, Georg Stingl, Martin Holcmann, Francesca Palamara, Maria Sibilia |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
medicine.medical_treatment
Immunology Population CD11c Imiquimod Antineoplastic Agents Biology Mice Immune system Dermis Cell Movement medicine Immunology and Allergy Animals education Melanoma Skin Inflammation MHC class II education.field_of_study hemic and immune systems Immunotherapy Dendritic Cells medicine.disease Flow Cytometry medicine.anatomical_structure biology.protein Aminoquinolines Spleen medicine.drug |
| Zdroj: | Journal of immunology (Baltimore, Md. : 1950). 173(5) |
| ISSN: | 0022-1767 |
| Popis: | Among the different subsets of dendritic cells (DC) described in humans and mice, epidermal Langerhans cells and dermal DCs represent the only DC populations resident in normal skin. In this study we describe a population of CD4+CD3− plasmacytoid DC (pDC)-like cells that accumulate in the dermis and spleens of mice topically treated with imiquimod, a low m.w. immune response modifier with potent antiviral and antitumor activities. These CD4+CD3− cells coexpress GR-1, B220, MHC class II, and, to a lesser extent, CD11c and display the phenotypic features of pDCs described in lymphoid organs. The accumulation of pDC-like cells after imiquimod treatment was detected not only in normal skin, but also in intradermally induced melanomas. Imiquimod treatment leads either to complete regression or to a significant reduction of the tumors. The number of pDCs correlates well with the clinical response of the tumors to the drug, suggesting that the antitumor effects of imiquimod could be mediated at least in part by the recruitment of pDC-like cells to the skin. Therefore, strategies aimed at activating and directing these cells into neoplastic tissues may be a promising and novel approach for the immunotherapy of various types of cancer. |
| Databáze: | OpenAIRE |
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