Vitamin D prevents lipid accumulation in murine muscle through regulation of PPARγ and perilipin-2 expression
| Autor: | Milton Mihalcioiu, Jiarong Li, Mahvash Zakikhani, Richard Kremer, Lifeng Li, Anne Camirand |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Vitamin medicine.medical_specialty Normal diet Endocrinology Diabetes and Metabolism Perilipin 2 Clinical Biochemistry Biochemistry Perilipin-2 vitamin D deficiency Mice 03 medical and health sciences chemistry.chemical_compound Endocrinology Pregnancy 3T3-L1 Cells Internal medicine Lipid droplet medicine Vitamin D and neurology Animals Vitamin D Muscle Skeletal Molecular Biology Serum Albumin Calcifediol 2. Zero hunger biology Skeletal muscle Lipid metabolism Vitamins Cell Biology Lipid Metabolism Vitamin D Deficiency medicine.disease Diet 3. Good health PPAR gamma 030104 developmental biology medicine.anatomical_structure chemistry biology.protein Molecular Medicine Calcium Female |
| Zdroj: | The Journal of Steroid Biochemistry and Molecular Biology. 177:116-124 |
| ISSN: | 0960-0760 |
| DOI: | 10.1016/j.jsbmb.2017.10.010 |
| Popis: | Vitamin D plays an important role in regulation of skeletal muscle tone and contraction. Serum vitamin D status is linked to muscle power and force in adolescent girls, and vitamin D deficiency is associated with myopathies in children and poorer physical performance in the elderly. We previously reported that vitamin D deficiency is linked to a significant increase in muscle fatty infiltration in healthy young women, and studies in patients with neuromuscular disorders also associate muscle weakening and lipid content. In order to better understand the link between vitamin D status and skeletal muscle lipid metabolism, we compared the effect of a low (25IU/kg) or normal (1000IU/kg) vitamin D3 diet on muscle fat in female FVB mice maintained in a room without UVB lighting to minimize endogenous vitamin D production. Animals on low vitamin D diet displayed lower circulating 25(OH)D levels and a dramatic increase (287±52% compared to normal diet, p |
| Databáze: | OpenAIRE |
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