Alzheimer’s disease treated patients showed different patterns for oxidative stress and inflammation markers
| Autor: | Demetrios Kouretas, Aristidis Tsatsakis, Konstantinos Tsarouhas, Mihaela Ilie, N Goutzourelas, Miriana Gubandru, Christina Tsitsimpikou, Denisa Margina |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Male
medicine.medical_specialty Homocysteine Population Glutathione reductase Arginine Toxicology medicine.disease_cause Antioxidants Protein Carbonylation chemistry.chemical_compound Alzheimer Disease Internal medicine medicine Humans Endothelial dysfunction Donepezil education Aged Aged 80 and over Inflammation education.field_of_study Interleukin-6 Tumor Necrosis Factor-alpha business.industry General Medicine Glutathione medicine.disease Malondialdehyde Oxidative Stress Endocrinology chemistry Case-Control Studies Immunology Female Endothelium Vascular business Biomarkers Oxidative stress Food Science medicine.drug |
| Zdroj: | Food and Chemical Toxicology. 61:209-214 |
| ISSN: | 0278-6915 |
| Popis: | Alzheimer's disease (AD) is the most common type of dementia accounting for 60-80% of the reported cases. The aim of this study was to evaluate levels of certain parameters of oxidative stress and markers of endothelial dysfunction in the blood of 21 AD patients under standard treatment compared with 10 controls, in an attempt to elucidate the contribution of AD to the total oxidative stress status of the patients. Results indicate that IL-6, TNF-α, ADMA and homocysteine levels were significantly elevated in AD patients. Protein carbonyls levels were higher in AD group, while glutathione reductase and total antioxidant capacity were lower, depicting decreased defense ability against reactive oxygen species. Besides, a higher level of advanced glycation end-products was observed in AD patients. Depending on the treatment received, a distinct inflammatory and oxidative stress profile was observed: in Rivastigmine-treated group, IL6 levels were 47% lower than the average value of the remaining AD patients; homocysteine and glutathione reductase were statistically unchanged in the Rivastigmine and Donepezil-Memantine, respectively Donepezil group. Although the study is based on a limited population, the results could constitute the basis for further studies regarding the effect of medication and diet on AD patients. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect