Are neurological abnormalities in well discordant monozygotic co-twins of schizophrenic subjects the result of perinatal trauma?
| Autor: | Robert R. Rawlings, Kenneth C. Rickler, Elizabeth Cantor-Graae, Edmund S. Higgins, Karin Sjöström, Thomas F. McNeil, Thomas M. Hyde |
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| Rok vydání: | 1994 |
| Předmět: |
Adult
Male medicine.medical_specialty Pediatrics Psychosis Substance-Related Disorders Poison control Monozygotic twin Comorbidity Neurological disorder Severity of Illness Index Pregnancy Birth Injuries Diseases in Twins medicine Humans Family Family history Psychiatry business.industry Twins Monozygotic medicine.disease Pregnancy Complications Psychiatry and Mental health Psychotic Disorders Schizophrenia Brain Injuries Etiology Female Nervous System Diseases business |
| Zdroj: | American Journal of Psychiatry. 151:1194-1199 |
| ISSN: | 1535-7228 0002-953X |
| DOI: | 10.1176/ajp.151.8.1194 |
| Popis: | Objective: Neurological abnormalities found in schizophrenic subjects and their healthy relatives have raised questions concerning etiology. The aim ofthe present study was to investigate the genetic and environmental antecedents of neurological impairment in monozygotic twins discordant for schizophrenia, with particular focus on the well discordant twins. The etiological factors of interest were history of obstetric complications, family history of psychosis, history ofsubstance abuse, and history ofpostnatal cerebral trauma. Method: History ofobstetric complications, including information from pregnancy through the neonatal period, and data on neurological “hard” and “soft” signs were obtained blindly and separately for each member of 22 monozygotic twin pairs discordant for schizophrenia and seven normal comparison monozygotic twin pairs. Clinical and family interviews provided information about background factors. Results: Degree ofneurological impairment in the well discordant monozygotic twins was significantly positively related to history of both neonatal and total obstetric complications. None of the three other background factors investigated was related to degree ofneurological impairment in the ill or well co-twins. Conclusions: The contribution of obstetric complications to the current level of neurological impairment in well discordant co-twins suggests that the spectrum ofneuroabnormality, ranging from neurological signs to schizophrenia, in monozygotic discordant twins may be the result ofsubtle gene-environment interaction. (AmJ Psychiatry1994; 151:1194-1199) |
| Databáze: | OpenAIRE |
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