Response to cardiac resynchronization therapy in non‐ischemic cardiomyopathy is unrelated to medical therapy
| Autor: | Samy Elayi, Hesham R. Omar, You W. Lin, Gregory Sinner, Maya Guglin |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Male
medicine.medical_specialty Heart Ventricles medicine.medical_treatment Clinical Investigations Cardiac resynchronization therapy Cardiomyopathy 030204 cardiovascular system & hematology Ventricular Function Left Cardiac Resynchronization Therapy Electrocardiography 03 medical and health sciences QRS complex 0302 clinical medicine Internal medicine Statistical significance medicine Humans cardiovascular diseases 030212 general & internal medicine Aged Retrospective Studies Ejection fraction business.industry Left bundle branch block Non ischemic cardiomyopathy Stroke Volume General Medicine Middle Aged medicine.disease Treatment Outcome Echocardiography cardiovascular system Cardiology Female Cardiomyopathies Cardiology and Cardiovascular Medicine business Anti-Arrhythmia Agents Medical therapy Follow-Up Studies circulatory and respiratory physiology |
| Zdroj: | Clinical Cardiology. 42:143-150 |
| ISSN: | 1932-8737 0160-9289 |
| DOI: | 10.1002/clc.23123 |
| Popis: | INTRODUCTION: Current guidelines recommend at least 3 months of guideline‐directed medical therapy (GDMT) for patients with a new onset of non‐ischemic cardiomyopathy (NICM) and left bundle branch block (LBBB) prior to cardiac resynchronization therapy (CRT). For patients who do not receive optimal GDMT, response to CRT is unknown. METHODS: Patients with NICM and LBBB with QRS ≥ 120 ms were identified among all patients who underwent CRT. Patients who received GDMT for ≥ 3 months before CRT were compared to those who did not. Among 38 patients who met inclusion criteria, 24 received optimal GDMT prior to implantation (Group 1) and 14 did not (Group 2). RESULTS: QRS narrowing occurred in Group 1 (160 ± 9 ms to 138 ± 20 ms, P = 0.001) and Group 2 (160 ± 17 ms to 139 ± 30 ms, P = 0.021). Left ventricular ejection fraction (LVEF) improvement occurred in Group 1 (21.3 ± 5.9% to 34.4 ± 13.9%, P < 0.001) and Group 2 (18.8 ± 4.7% to 31.1 ± 13%, P = 0.010). QRS interval and LVEF changes were similar between groups (P = NS). There was a trend towards greater CRT response in women than in men, although differences did not reach statistical significance. CONCLUSION: In patients with NICM and LBBB, CRT is associated with improvements in LV size and function independent of prior GDMT. The ability of resynchronization to improve LVEF without GDMT suggests that CRT without waiting 3 months for GDMT optimization may benefit some patients with NICM and LBBB. |
| Databáze: | OpenAIRE |
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