Asymmetrical zinc(II) phthalocyanines conjugated to metal tungstate nanoparticles for photoinactivation of Staphylococcus aureus

Autor:	Sithi Mgidlana, Muthumuni Managa, Tebello Nyokong
Rok vydání:	2022
Předmět:	Materials Chemistry Physical and Theoretical Chemistry
Zdroj:	Journal of Coordination Chemistry. 75:1097-1111
ISSN:	1029-0389 0095-8972
Popis:	In this study, we report for the first time on the photodynamic antimicrobial chemotherapy (PACT) of asymmetrical zinc(II) phthalocyanines and their conjugates with nickel tungstate (NiWO4), cobalt tungstate (CoWO4) and bismuth tungstate (Bi2WO6) nanoparticles. CoWO4, NiWO4 and Bi2WO6 were capped with glutathione and covalently linked to three asymmetrical zinc(II) phthalocyanines for PACT. The plate count method was used to investigate the effect of covalently linking asymmetrical zinc(II) phthalocyanines to nanoparticles under light (for PACT against Staphylococcus aureus) and in the dark. Both Pc complexes and the conjugates indicated minimum dark-toxicity. The conjugates showed greater antimicrobial activity against a gram-positive and drug resistant bacteria, Staphylococcus aureus, than Pc complexes alone.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::320d08063f27d1ddcba458ed04b45f5a https://doi.org/10.1080/00958972.2022.2090837 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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