Prognostic Value of Histopathological Features and Loss of H3K27me3 Immunolabeling in Anaplastic Meningioma: A Multicenter Retrospective Study
| Autor: | Dominique Cazals-Hatem, Matthieu Peyre, Michel Kalamarides, Franck Bielle, Fabien Rech, Hugues Loiseau, Karima Mokhtari, Guillaume Gauchotte, Celso Pouget, Stéphanie Lacomme, Pascale Varlet, Marc Polivka |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male Jumonji Domain-Containing Histone Demethylases medicine.medical_specialty Multivariate analysis Mitotic index Intraclass correlation Gastroenterology Pathology and Forensic Medicine Meningioma Young Adult 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Internal medicine Biomarkers Tumor Meningeal Neoplasms medicine Humans Anaplasia Aged Retrospective Studies Aged 80 and over Reproducibility business.industry Retrospective cohort study General Medicine Middle Aged Prognosis medicine.disease Survival Rate Neurology 030220 oncology & carcinogenesis Female Neurology (clinical) medicine.symptom business 030217 neurology & neurosurgery Kappa Follow-Up Studies |
| Zdroj: | Journal of Neuropathology & Experimental Neurology. 79:754-762 |
| ISSN: | 1554-6578 0022-3069 |
| DOI: | 10.1093/jnen/nlaa038 |
| Popis: | The diagnosis of anaplastic meningioma (AM) (WHO grade III) is based on the presence of a high mitotic index (MI) and/or overt anaplasia. Only few data exist about the reproducibility and prognostic value of overt anaplasia. Additionally, the prognostic value of H3K27me3 loss in AM has not yet been demonstrated. Our objectives were to evaluate the reproducibility and prognostic value of WHO criteria and H3K27me3 loss in a multicenter series of 66 AM. Interobserver reproducibility was good for the determination of WHO grade (Kappa = 0.671) and MI (intraclass correlation coefficient [ICC] = 0.649), and fair for assessment of overt anaplasia (Kappa = 0.366). Patients with meningiomas showing high MI had significantly shorter overall survival (OS) than patients with meningiomas showing overt anaplasia without high MI (p = 0.009). OS was significantly lower in case of overt anaplasia with low MI ( |
| Databáze: | OpenAIRE |
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