| Autor: |
Ashley Tabah, David Huggar, Si-Tien Wang, Scott J Johnson, Ronda M Copher, Thomas O'Connell, Ali McBride, Thomas W LeBlanc |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Future oncology (London, England). |
| ISSN: |
1744-8301 |
| Popis: |
Aim: Evaluate the relative efficacy of oral versus injectable azacitidine (AZA) maintenance therapy in acute myeloid leukemia (AML) after complete remission. Materials & methods: Systematic literature review identified QUAZAR AML-001, HOVON 97 AML, UK NCRI AML16 and QoLESS-AZA-AMLE (sensitivity analysis) trials. Network meta-analysis and matching-adjusted indirect comparisons assessed survival outcomes. Results: In the network meta-analysis, combining the HOVON 97 and UK NCRI trials, oral AZA (QUAZAR) was associated with significantly improved overall survival (OS) versus injectable AZA (hazard ratio: 0.744; 95% credible interval: 0.557–0.998). After matching-adjusted indirect comparisons, to address differences in patient characteristics across trials, OS improvements were maintained with oral versus injectable AZA (hazard ratio: 0.753; credible interval: 0.563–0.998). Conclusion: In AML, maintenance therapy with oral AZA was associated with improved OS versus injectable AZA. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
