Live birth after fresh versus frozen single blastocyst transfer (Frefro-blastocyst): study protocol for a randomized controlled trial

Autor: Yi-Min Zhu, Jiayin Liu, Xiaoyan Liang, Yuhua Shi, Yun Sun, Zi-Jiang Chen, Daimin Wei
Rok vydání: 2017
Předmět:
Time Factors
Pregnancy Rate
medicine.medical_treatment
Medicine (miscellaneous)
Intracytoplasmic sperm injection
Embryo Culture Techniques
Study Protocol
0302 clinical medicine
Clinical Protocols
Pregnancy
Pharmacology (medical)
030212 general & internal medicine
reproductive and urinary physiology
lcsh:R5-920
030219 obstetrics & reproductive medicine
Blastocyst Transfer
Embryo transfer
Treatment Outcome
medicine.anatomical_structure
Research Design
Randomized controlled trial
embryonic structures
Female
lcsh:Medicine (General)
Live birth
Live Birth
Adult
China
medicine.medical_specialty
Single Embryo Transfer
Fertilization in Vitro
Andrology
Young Adult
03 medical and health sciences
Ovulation Induction
medicine
Humans
Sperm Injections
Intracytoplasmic
Blastocyst
Singleton live birth
Cryopreservation
Gynecology
Single embryo transfer
In vitro fertilisation
business.industry
Embryo culture
Fertility
Infertility
business
Zdroj: Trials, Vol 18, Iss 1, Pp 1-7 (2017)
Trials
ISSN: 1745-6215
Popis: Background Multiple pregnancies are one of the major safety concerns of in vitro fertilization (IVF) due to the increased risk of maternal and neonatal complications. Single embryo transfer is the most effective way to reduce the risk of multiple pregnancies. Selection of the embryo and optimization of the implantation environment are crucial to retain the success rate when the number of transferred embryos is diminished. Fresh embryo transfer with supra-physiological levels of hormones has been suggested to have an adverse effect on implantation. Elective frozen embryo transfer has been suggested to result in a higher rate of live birth than fresh embryo transfer. However, there is still a lack of evidence from randomized clinical trials comparing the efficacy and safety between frozen and fresh single blastocyst transfers. Methods/design We are conducting a randomized controlled trial in women aged 20–35 undergoing their first cycle of IVF with or without intracytoplasmic sperm injection. After ovarian stimulation with a gonadotropin-releasing hormone antagonist protocol, women who obtain four or more embryos on day 3 of the embryo culture are randomized into two parallel groups: a single fresh blastocyst transfer group and a single frozen blastocyst transfer group (all blastocysts vitrified and a deferred frozen blastocyst transfer). The primary outcome is singleton live birth. Discussion The results of this study will provide evidence for the efficacy and safety of the strategy of elective frozen single blastocyst transfer in women with a good prognosis. Trial registration Chinese Clinical Trial Registry, ChiCTR-IOR-14005405. Registered on 30 Oct 2014. Electronic supplementary material The online version of this article (doi:10.1186/s13063-017-1993-5) contains supplementary material, which is available to authorized users.
Databáze: OpenAIRE
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