Effect of non-surgical periodontal therapy on insulin resistance and insulin sensitivity among individuals with borderline diabetes: A randomized controlled trial
| Autor: | Takeshi Tanigawa, Haruhiko Osawa, Noriko Miyoshi, Isao Saito, Wataru Nishida, Eri Eguchi, Koutatsu Maruyama, Shinji Nishioka |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Blood Glucose
medicine.medical_specialty medicine.medical_treatment Bleeding on probing Body Mass Index law.invention 03 medical and health sciences 0302 clinical medicine Scaling and root planing Insulin resistance Randomized controlled trial law Internal medicine Diabetes mellitus Diabetes Mellitus medicine Humans Insulin Clinical significance 030212 general & internal medicine General Dentistry business.industry Fasting 030206 dentistry medicine.disease Diabetes Mellitus Type 2 Periodontics Insulin Resistance medicine.symptom business Body mass index |
| Zdroj: | Journal of Dentistry. 85:18-24 |
| ISSN: | 0300-5712 |
| Popis: | To investigate the effect of non-surgical periodontal therapy on insulin resistance and sensitivity among individuals with borderline diabetes not receiving medications.A crossover, randomized controlled trial was conducted among participants with borderline diabetes diagnosed by a 75-g oral glucose tolerance test. Participants were randomly assigned to either an early or later intervention group. The early intervention group underwent non-surgical periodontal therapy of scaling and root planing during the first 6 months, followed by a 6-month non-intervention period. The order was reversed in the later intervention group. Primary outcomes included: fasting or post-load serum glucose and insulin, body mass index (BMI), HOMA-IR, HOMA-β, and Matsuda Index.Seventy-four participants were randomized, and 71 participants completed the trial. There were no significant differences between groups in glucose and insulin concentrations during the intervention and non-intervention periods. When analyzed within groups by median-split of bleeding on probing (BOP) levels before intervention, the lower BOP group showed improved changes in BMI, HOMA-IR, HOMA-β, and Matsuda Index (P 0.05). Further, we observed a positive correlation between baseline BOP and change in BMI (P = 0.06). Change in BMI was positively correlated with changes in HbAPeriodontal therapy had no significant effect on markers related to insulin and glucose metabolism among individuals with borderline diabetes. However, participants with a lower BOP (%) showed significant improvements in BMI, fasting serum insulin, HOMA-IR, HOMA-β and Matsuda Index.Among individuals diagnosed with borderline diabetes, those who had37% of a lower BOP (%) showed potential improvements in BMI, fasting serum insulin, HOMA-IR, HOMA-β and Matsuda Index following non-surgical periodontal therapy. |
| Databáze: | OpenAIRE |
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