Solid-Phase Synthesis and Photophysical Properties of DNA Labeled at the Nucleobase with Ru(bpy)(2)(4-m-4'-pa-bpy)(2+)

Autor:	Mark W. Grinstaff, Mark T. Tierney, Milan Sykora, Amy E. Beilstein, Shoeb I. Khan
Rok vydání:	2001
Předmět:	Inorganic Chemistry chemistry.chemical_compound Solid-phase synthesis chemistry Oligonucleotide Covalent bond Physical and Theoretical Chemistry Combinatorial chemistry DNA Diimine Nucleobase
Zdroj:	Inorganic chemistry. 38(26)
ISSN:	1520-510X
Popis:	A facile procedure for incorporating a Ru(diimine)(3)(2+) complex at the nucleobase in an oligonucleotide is reported that combines the advantages of Pd(0) cross-coupling and solid-phase DNA chemistries. These ruthenium-modified oligonucleotides form stable duplexes, and the favorable photophysical properties associated with the Ru(diimine)(3)(2+) complex are retained after site-specific covalent attachment.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::320367ce43dc1152666fc21f9eadf7ff https://pubmed.ncbi.nlm.nih.gov/11671306 Zobrazit plný text záznamu