Pregnancy-induced hypertension is associated with down-regulation of Kir6.1 in human myometrium
| Autor: | Qingyou Du, Sofija Jovanović, Ivan Tulić, Lidija Tulić, Aleksandar Jovanović |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Adult
endocrine system medicine.medical_specialty Human myometrium Protein subunit Uterus Down-Regulation 030204 cardiovascular system & hematology Real-Time Polymerase Chain Reaction 03 medical and health sciences 0302 clinical medicine Downregulation and upregulation KATP Channels Pregnancy Internal medicine Internal Medicine medicine Humans In patient RNA Messenger Membrane potential 030219 obstetrics & reproductive medicine business.industry Obstetrics and Gynecology Hypertension Pregnancy-Induced medicine.disease medicine.anatomical_structure Endocrinology Case-Control Studies Myometrium Pregnancy induced Female business |
| Zdroj: | Pregnancy hypertension. 18 |
| ISSN: | 2210-7797 |
| Popis: | It is generally accepted that activity of K+ channels maintain resting membrane potential and uterine quiescence during pregnancy, which is, at least in part, mediated by down-regulation of ATP-sensitive K+ (KATP) channels. Pregnancy-induced hypertension (PIH) is associated with pre-term and late pre-term labour. Here, we have used real time RT-PCR to compare mRNA levels of KATP channel subunits in PIH parturient and control parturient. We have found that Kir6.1, a pore forming, myometrial KATP channel subunit is down-regulated in PIH patients. This could perfectly explain increased rate of pre-term labour in patients suffering from PIH. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect