Reproductive factors and risks of biliary tract cancers and stones: a population-based study in Shanghai, China
| Autor: | Ming-Chang Shen, Bingsheng Wang, Louise A. Brinton, Asif Rashid, Gabriella Andreotti, Ann W. Hsing, J. F. Fraumeni, Lifang Hou, B. H. Zhang, Jinbo Chen, Lori C. Sakoda, Tian-Quan Han, Yu-Tang Gao |
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| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
Cancer Research
medicine.medical_specialty China Epidemiology Population Gallbladder disease Gallstones Gastroenterology Bile duct cancer Pregnancy Risk Factors Internal medicine biliary tract cancer medicine Odds Ratio Humans Gallbladder cancer education Demography education.field_of_study Obstetrics business.industry Gallbladder Reproduction Odds ratio medicine.disease Parity medicine.anatomical_structure Biliary Tract Neoplasms Oncology Case-Control Studies Menarche Female Gallbladder Neoplasms reproductive factors business |
| Zdroj: | British Journal of Cancer |
| ISSN: | 1532-1827 0007-0920 |
| Popis: | Background: Parity has been linked to gallbladder cancer and gallstones, but the effects of other reproductive factors are less clear. Methods: We examined 361 incident biliary tract cancer cases, 647 biliary stone cases, and 586 healthy women in a population-based study in Shanghai. Results: The effects of parity (odds ratios, OR⩾3 vs 1 child=2.0, 95% confidence interval (CI) 0.7–5.1), younger age at first birth (ORper 1-year decrease=1.2, 95% CI 0.99–1.6), and older age at menarche (ORper 1-year increase=1.4, 95% CI 1.1–1.8) on gallbladder cancer risk were more pronounced among women with stones, but the interactions were not significant. Conclusion: Our results provide support for high parity, younger age at first birth, and late age at menarche in the development of gallbladder cancer, particularly among women with biliary stones. |
| Databáze: | OpenAIRE |
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